How the body learns what hurts, what itches, and how to heal.

Dong X, Follansbee T, Kim B, eds. The Itch Spectrum: The Neurological and Immunological Basis of Itch and Dermatological Disorders. Elsevier, in press (Book, editor)

Kothari R, Dong X. The Neuroimmune Axis: Integrating Two Systems to Decipher Itch. Neuron 2026 online (Review)

Roger A, Fohrer T, Mardelle U, Thomas I, Teimouri Nezhad S, Gupta S, Dory A, Jeyanathan V, Liaghat A, Mielle J, Medjouel Khlifi H, Santamaria JC, Brunet E, Gouilly J, Escaliere B, Bretaud N, Crosson T, Barbon PV, Mossadegh-Keller N, Irla M, Basta S, Broggi A, Milpied P, Gour N, Feuillet V, Hoeffel G, Dong X, Kaufmann E, Reynders A, Talbot S, Moqrich A, Ugolini S. Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection. Immunity 2026 online

Koui Y, Song S, Dong X, Mukouyama Y. Local keratinocyte-nociceptor interactions enhance obesity-mediated painful small fiber neuropathy via NGF-TrkA-PI3K signaling axis. iScience 2025 28 (3)

Hsiao MH, Miao Y, Liu Z, Schütze K, Limjunyawong N, Chien DC, Monteiro WD, Chu LS, Morgenlander W, Jayaraman S, Jang S, Gray JJ, Zhu H, Dong X, Steinegger M, Larman HB. Molecular Display of the Animal Meta-Venome for Discovery of Novel Therapeutic Peptides. Molecular & Cellular Proteomics, 2025 24 (2)

Xie W, Lückemeyer DD, Qualls KA, Berta T, Gu M, Strong JA, Dong X, Zhang JM. Vascular motion in the DRG sensed by Piezo2 in sensory neurons triggers episodic neuropathic pain. Neuron 2025 113 (11), 1774-1788.

Israel MR, Berwick R, Vastani N, Zheng Q, Moore W, Maurer M, Gentry C, Marshall A, Sun H, Neiland H, Dunham J, Bouchatta O, Plant K, Nagi SS, Olausson H, Alam U, Dong X, Bevan S, Marshall A, Goebel A, Andersson DA. Aβ low threshold mechanoreceptors contribute to sensory abnormalities in fibromyalgia. Brain 2025 awaf321

Kline SN, Feller LE, Saito Y, Dikeman D, Youn C, Wang Y, Li Z, Wu MJ, Zhang J, Pontaza C, Hunat JC, Pham CTN, Dong X, Archer NK. Epicutaneous Staphylococcus aureus initiates cross-tissue IL-36R signaling for neutrophilic lung inflammation in a model of the atopic march. Cell Reports 2025 44 (8)

Cheng HY, Chu J, Limjunyawong N, Chen J, Ye Y, Chen KH, Koylass N, Sun S, Dong X, Qiu Z. Proton-activated chloride channel governs phagosome-mediated antibacterial immunity in peritoneal macrophages. Journal of Experimental Medicine 2025 222 (11), e20250312

Uniyal A, Hin N, Zhang C, Xu Q, Huang Q, Berhane I, Thomas AG, Maragakis J, Gori S, Liu J, Zheng Q, Cui X, Peng Q, Wan J, Rais R, Slusher BS, Raja SN, Dong X, Tsukamoto T, Guan Y. An orally bioavailable MrgprX1-positive allosteric modulator alleviates certain neuropathic pain–related behaviors in humanized mice. Science translational medicine 2025 17 (829), eadw9446

Abdulrahim MW, Chen Y, Nair SK, Xu Q, Zhang Y, Das O, Gensler R, Feghali J, Ahmed AK, Jackson CM, Huang J, Comair YG, Bettegowda C, Dong X, Risheng Xu R. A mouse model of classical trigeminal neuralgia via intradural compression of the trigeminal nerve. The Journal of Headache and Pain 2025 25

Mamuladze T, Zaninelli TH, Smyth LCD, Wu Y, Abramishvili D, Silva R, Imbiakha B, Verhaege D, Du S, Papadopoulos Z, Gu X, Lee D, Storck S, Perrin RJ, Smirnov I, Dong X, Hu S, Diamond MS, Pinho-Ribeiro FA, Kipnis J. Mast cells regulate the brain-dura interface and CSF dynamics Cell 2025 188 (20), 5487-5498

Kothari R, Abdulrahim MW, Oh HJ, Capuzzi DH, Kilgore CB, Nair SK, Zhang Y, Limjunyawong N, Saini SS, Kim JE, Caplan JM, Gonzalez FL, Jackson CM, Bettegowda C, Huang J, Ganesh BP, Tan C, Koehler RC, Tamargo RJ, McCullough LD, Xu R, Dong X. A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis. Cell 2025 188 (20), 5499-5515, cover article

Gour N, Dong X. The MRGPR family of receptors in immunity. Immunity 2024 57 (1), 28-39 (Review)

Remoortel SV, Lambeets L, Winter BD, Dong X, Ruiz JPR, Kumar-Singh S, Martinez SI, Timmermans JP. Mrgprb2-dependent mast cell activation plays a crucial role in acute colitis. Cellular and Molecular Gastroenterology and Hepatology 2024 18 (5), 101391

Cai W, Zhang W, Zheng Q, Hor CC, Fatima M, Dong X, Duan B, Xu XZS. The kainate receptor GluK2 mediates cold sensing in mice. Nature Neuroscience 2024; 27 (4), 679-688.

Kline SN, Orlando NA, Lee AJ, Wu MJ, Zhang J, Youn C, Feller LE, Pontaza C, Dikeman D, Limjunyawong N, Williams KL, Wang Y, Cihakova D, Jacobsen EA, Durum SK, Garza LA, Dong X, Archer NK. Staphylococcus aureus proteases trigger eosinophil-mediated skin inflammation. PNAS 2024; 121 (6).

Gour N, Yong HM, Magesh A, Atakkatan A, Andrade F, Lajoie S, Dong X. A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection. Immunity 2024; 57 (2): 333-348.

Follansbee TL, Chang HL, Carstens ML, Guan Y, Carstens E, Dong X. Optotagging and characterization of GABAergic rostral ventromedial medulla (RVM) neurons. Molecular Pain 2024; 17448069241270295.

Patel JR, Joel MZ, Lee KK, Kambala A, Cornman H, Oladipo O, Taylor M, Imo BU, Ma EZ, Manjunath J, Kollhoff AL, Deng J, Parthasarathy V, Cravero K, Marani M, Szeto M, Zhao R, Sankararaman S, Li R, Henry S, Pritchard T, Rebecca V, Kwatra MM, Ho WJ, Dong X, Kang S, Kwatra SG. Single-cell RNA sequencing reveals dysregulated POSTN+ WNT5A+ fibroblast subclusters in prurigo nodularis. Journal of Investigative Dermatology 2024 144 (7), 1568-1578. e5

Chien DC, Limjunyawong N, Cao C, Meixiong J, Peng Q, Ho CY, Fay JF, Roth BL, Dong X. MRGPRX4 mediates phospho-drug associated pruritus. Science Translational Medicine 2024; 16: eadk8198.

Zhang C, Huang Q, Ford NC, Limjunyawong N, Lin Q, Yang F, Cui X, Uniyal A, Liu J, Mahabole M, He H, Wang XW, Duff U, Wang Y, Wan J, Zhu G, Raja SN, Jia H, Yang D, Dong X, Cao X, Tseng SC, He SQ, Guan Y. Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain eLife 2024 13

Limerick G, Uniyal A, Ford N, He SQ, Grenald SA, Zhang C, Cui X, Sivanesan E, Dong X, Guan Y, Raja SN. Peripherally restricted cannabinoid and mu-opioid receptor agonists synergistically attenuate neuropathic mechanical hypersensitivity in mice. Pain 2024 165 (11), 2563-2577

Serafin EK, Yoo JJ, Li J, Dong X, Baccei ML. Development and characterization of a Gucy2d-cre mouse to selectively manipulate a subset of inhibitory spinal dorsal horn interneurons. PloS one 2024 19 (3), e0300282

Hong I, Kim J, Hainmueller T, Kim DW, Keijser J, Johnson RC, Park SH, Limjunyawong N, Yang Z, Cheon D, Hwang T, Agarwal A, Cholvin T, Krienen FM, McCarroll SA, Dong X, Leopold DA, Blackshaw S, Sprekeler H, Bergles DE, Bartos M, Brown SP, Huganir RL. Calcium-permeable AMPA receptors govern PV neuron feature selectivity. Nature 2024 635 (8038), 398-405

Rodrigo M, Dong X, Chien D, Karnsakul W. Cholestatic Pruritus in Children: Conventional Therapies and Beyond. Biology 2023 12 (5), 756 (Review)

Guan LC, Dong X, Green DP. Roles of mast cells and their interactions with the trigeminal nerve in migraine headache. Molecular Pain 2023 17448069231181358 (Review)

Follansbee T, Dong X. A tactile twist: decoding the phenomena of mechanical itch and alloknesis. Frontiers in Molecular Neuroscience 2023 16. (Review)

Uniyal A, Tiwari V, Tsukamoto T, Dong X, Guan Y, Raja SN. Targeting sensory neuron GPCRs for peripheral neuropathic pain. Trends in Pharmacological Sciences 2023 (Review)

Wang P, Zhang Q, Dias FC, Suttle A, Dong X, Chen Y. TMEM100, a regulator of TRPV1-TRPA1 interaction, contributes to temporomandibular disorder pain. Frontiers in Molecular Neuroscience 2023; 16: 1160206.

Lu P, Zhao Y, Xie Z, Zhou H, Dong X, Wu GF, Kim BS, Feng J, Hu H. MrgprA3-expressing pruriceptors drive pruritogen-induced alloknesis through mechanosensitive Piezo2 channel. Cell Reports 2023; 42 (4).

Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Xu HE, Sun JP. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nature Communications 2023; 14 (1): 5004.

Yuan Y, Yee R, Gour N, Dong X, Feng J, Shi W, Zhang Y. Identification of persister drug combination clinafloxacin + cefuroxime + gentamicin that eradicates persistent Pseudomonas aeruginosa infection in a murine cystic fibrosis model. Infectious Microbes & Disease 2023; 5 (1): 21-28.

Yang Y, Sun Y, Zhu C, Shen X, Sun J, Jing T, Jun S, Wang C, Yu G, Dong X, Sheng M, Tang Z. Allantoin induces pruritus by activating MrgprD in chronic kidney disease. Journal of Cellular Physiology 2023; 238 (4): 813-828.

Zhang M, Zhang Y, Xu Q, Crawford J, Qian C, Wang GH, Qian J, Dong X, Pletnikov MV, Liu C, Zhou FQ. Neuronal Histone Methyltransferase EZH2 regulates neuronal morphogenesis, synaptic plasticity, and cognitive behavior in mice. Neuroscience Bulletin 2023; 1-21.

Serafin E, Yoo J, Eid F, Dong X, Baccei M. Development and characterization of Gucy2d-Cre mice to manipulate a subset of inhibitory spinal dorsal horn interneurons. The Journal of Pain 2023; 24: 26-27.

Li Q, Mathena RP, Li F, Dong X, Guan Y, Mintz CD. Effects of early exposure to isoflurane on susceptibility to chronic pain are mediated by increased neural activity due to actions of the mammalian target of the rapamycin pathway. International Journal of Molecular Sciences 2023; 24.

Tauber M, Basso L, Martin J, Bostan L, Pinto MM, Thierry GR, Houmadi R, Serhan N, Blériot C, Kamphuis JBJ, Grujic M, Kjellén L, Pejler G, Paul C, Dong X, Galli SJ, Reber LL, Ginhoux F, Bajenoff M, Gentek R, Gaudenzio N. Landscape of mast cell populations across organs in mice and humans. Journal of Experimental Medicine 2023; 220 (10).

Trier AM, Ver Heul A, Fredman A, Le V, Wang Z, Auyeung K, Meixiong J, Lovato P, Holtzman MJ, Wang F, Dong X, Ji AL, Kim BS. IL-33 potentiates histaminergic itch. Journal of Allergy and Clinical Immunology 2023, 153 (3), 852-859.

Kothari R, Dong X. Scratching the surface of itch receptors. Trends in Pharmacological Sciences 2022 (Review)

Follansbee T, Dong X. Touch-evoked itch pinned on Piezo1 ion-channel protein. Nature 2022 607, 36-37 (Review)

Zheng Q, Dong XT, Green DP, Dong XZ. Peripheral mechanisms of chronic pain. Medical Review 2022 2(3): 251-270 (Review)

Trier A, Ver Heul AV, Fredman A, Meixong J, Wang F, Dong X, Kim B. IL-33 enhances histaminergic itch. J Allergy Clin Immunol. 2022; 149: AB176.

Berhane I, Hin N, Thomas AG, Huang Q, Zhang C, Veeravalli V, Wu Y, Ng J, Alt J, Rojas C, Hihara H, Aoki M, Yoshizawa K, Nishioka T, Suzuki S, He SQ, Peng Q, Guan Y, Dong X, Raja SN, Slusher BS, Rais R, Tsukamoto T. Thieno[2,3-d]pyrimidine-based positive allosteric modulators of human Mas-related G protein-coupled receptor X1 (MRGPRX1). J Med Chem. 2022. 65 (4), 3218-3228

Zheng Q, Xie W, Lückemeyer DD, Lay M, Wang XW, Dong X, Limjunyawong N, Ye Y, Zhou FQ, Strong JA, Zhang JM, Dong X. Synchronized cluster firing, a distinct form of sensory neuron activation, drives spontaneous pain. Neuron. 2022; 2: 209-220.

Vasavda C, Semenza ER, Liew J, Kothari R, Dhindsa RS, Shanmukha S, Lin A, Tokhunts R, Ricco C, Snowman AM, Albacarys L, Pastore F, Ripoli C, Grassi C, Barone E, Kornberg MD, Dong X, Paul BD, Snyder SH. Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling. Sci Signal. 2022; 15(733): eabh3066.

Ford NC, Barpujari A, He SQ, Huang Q, Zhang C, Dong X, Guan Y, Raja SN. Role of primary sensory neurone cannabinoid type-1 receptors in pain and the analgesic effects of the peripherally acting agonist CB-13 in mice. Br J Anaesth. 2022; 128: 159-173.

Chen Z, Zhang C, Song X, Cui X, Liu J, Ford NC, He S, Zhu G, Dong X, Hanani M, Guan Y. BzATP activates satellite glial cells and increases the excitability of dorsal root ganglia neurons in vivo. Cells. 2022; 11(15): 2280.

Feng J, Zhao Y, Xie Z, Zang K, Sviben S, Hu X, Fitzpatrick JAJ, Wen L, Liu Y, Wang T, Lawson K, Liu Q, Yan Y, Dong X, Han L, Wu GF, Kim BS, Hu H. Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle. Sci Transl Med. 2022; 14(653): eabn4819.

Sharma S, Peng Q, Vadukoot AK, Aretz CD, Jensen AA, Wallick AI, Dong X, Hopkins CR. Synthesis and biological characterization of a series of 2-sulfonamidebenzamides as allosteric modulators of MrgX1. ACS Med Chem Lett. 2022; 13: 841-847.

Wang C, Green DP, Dong X. Transcription factor MAFA regulates mechanical sensation by modulating Piezo2 expression. Neurosci Bull. 2022. 38 (8), 933-937.

Dong XT, Limyunyawong N, Wang G, Sypek EI, Ortines RV, Lay M, Dikeman D, Wang Y, Miller LS, Lu W, Kim B, Garz LA, Archer NK, Dong XZ. Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022; 55: 1645-1662.

Yang F, Limjunyawong N, Peng Q, Schroeder J, Saini S, MacGlashan D, Dong X, Gao L. Biological screening of a unique drug library targeting MRGPRX2. Frontiers in Immunology 2022; 13.

Kim H, Kim H, Cho H, Lee B, Lu HJ, Kim K, Chung S, Shim WS, Shin YK, Dong X, Wood JN, Oh U. Anoctamin 1/TMEM16A in pruritoceptors is essential for Mas-related G protein receptor–dependent itch. Pain 2022; 163: 2172-2184.

Patil MJ, Huang Y, Yu M, Dong X, Undem BJ, Yu S. Ginger constituent 6-shogaol attenuates vincristine-induced activation of mouse gastroesophageal vagal afferent C-fibers. Molecules 2022; 27: 7465.

Vasavda C, Xu R, Liew J, Kothari R, Dhindsa RS, Semenza ER, Paul BD, Green DP, Sabbagh MF, Shin JY, Yang W, Snowman AM, Albacarys LK, Moghekar A, Pardo-Villamizar CA, Luciano M, Huang J, Bettegowda C, Kwatra SG, Dong X, Lim M, Snyder SH. Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Science Advances 2022; 8: eabo5633.

Trier AM, Ver Heul A, Fredman A, Meixong J, Wang F, Dong X, Kim B. IL-33 enhancement of histaminergic itch is dependent on IL-13. Journal of Investigative Dermatology 2022; 142 (8): B25.

Youn C, Dikeman DA, Chang E, Liu H, Nolan SJ, Alphonse MP, Joyce DP, Liu Q, Meixiong J, Dong X, Miller LS, Archer NK. Crisaborole efficacy in murine models of skin inflammation and Staphylococcus aureus infection. Experimental Dermatology 2022 32 (4), 425-435.

Shtessel M, Limjunyawong N, Oliver ET, Chichester K, Gao L, Dong X, Saini SS. MRGPRX2 Activation Causes Increased Skin Reactivity in Patients with Chronic Spontaneous Urticaria. The Journal of Investigative Dermatology 2021: 141(3): 678-681.

Huang J, Lam H, Koziol-White C, Limjunyawong N, Kim D, Kim N, Karmacharya N, Rajkumar P, Firer D, Pluznick JL, Deshpande DA, Penn RB, Liggett SB, Panettieri RA, Dong X, An SS. The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. PNAS 2021: 117(45): 28485-28495.

Wang F, Trier AM, Li F, Kim S, Chen Z, Chai JN, Mack MR, Morrison SA, Hamilton JD, Baek J, Yang TB, Ver Heul AK, Xu AZ, Xie Z, Dong XT, Kubo M, Hu H, Hsieh CS, Dong XZ, Liu Q, Margolis DJ, Ardeleanu M, Miller MJ, Kim BS. A basophil-neuronal axis promotes itch. Cell 2021: 184(2): 422-440.

Sun Q, Zhen G, Li TP, Guo Q, Li Y, Su W, Xue P, Wang X, Wan M, Guan Y, Dong X, Li S, Cai M, Cao X. Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice. Elife. 2021; 10: e66532.

Wolf K, Kühn H, Boehm F, Gebhardt L, Glaudo M, Agelopoulos K, Stander S, Ectors P, Zahn D, Riedel YK, Thimm D, Muller CE, Kretschmann S, Kremer AN, Chien D, Limjunyawong N, Peng Q, Dong X, Klkhir P, Scheffel J, Sogaard ML, Weigmann B, Neurath MF, Hawro T, Metz M, Fischer MJM, Kremer AE. A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice. J Allergy Clin Immunol. 2021. 148 (2). 506-522.

Klein A, Solinski HJ, Malewicz NM, Ieong HF, Sypek EI, Shimada SG, Hartke TV, Wooten M, Wu G, Dong X, Hoon MA, LaMotte RH, Ringkamp M. Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates. Elife. 2021; 10: e64506.

Zaufel A, van de Wiel S, Yin L, Fauler G, Chien D, Dong X, Gilmer JF, Truong JK, Dawson PA, van de Graaf S, Fickert P, Moustafa T. Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions. Biochim Biophys Acta Mol Basis Dis. 2021; 1867(8): 166153.

Wongvibulsin S, Sutaria N, Kannan S, Alphonse MP, Belzberg M, Williams KA, Brown ID, Choi J, Roh YS, Pritchard T, Khanna R, Eseonu AC, Jedrych J, Dillen C, Kwatra MM, Chien AL, Archer N, Garza LA, Dong X, Kang S, Kwatra SG. Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation. Sci Rep. 2021; 11(1): 1-11.

Sun Q, Zhen G, Li TP, Guo Q, Li Y, Su W, Xue P, Wang X, Wan M, Guan Y, Dong X, Li S, Cai M, Cao X. Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice. Elife. 2021; 10: e66532.

Gao X, Han S, Huang Q, He S, Ford NC, Zheng Q, Chen Z, Yu S, Dong X, Guan Y. Calcium imaging in population of dorsal root ganglion neurons unravels novel mechanisms of visceral pain sensitization and referred somatic hypersensitivity. Pain. 2021; 16(4): 1068-1081.

Sutaria N, Alphonse MP, Marani M, Parthasarathy V, Deng J, Wongvibulsin S, Williams K, Roh YS, Choi J, Bordeaux Z, Pritchard T, Dillen C, Semenov YR, Kwatra MM, Archer NK, Garza LA, Dong X, Kang S, Kwatra SG. Cluster analysis of circulating plasma biomarkers in prurigo nodularis reveals a distinct systemic inflammatory signature in African Americans. J Invest Dermatol. 2021. 142 (5), 1300-1308.

Grundy L, Caldwell A, Garcia-Caraballo S, Grundy D, Spencer NJ, Dong X, Castro J, Harrington AM, Brierley SM. Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension. J Neurosci. 2021; 41(17): 3900-3916.

Lawrence GW, Zurawski TH, Dong X, Dolly JO. Population coding of capsaicin concentration by sensory neurons revealed using Ca2+ imaging of dorsal root ganglia explants from adult pirt-GCaMP3 mouse. Cell Physiol Biochem. 2021; 55: 428-448.

Chen Z, Huang Q, Song X, Ford NC, Xu Q, Lay M, He SQ, Dong X, Hanani M, Guan Y. Purinergic signaling between neurons and satellite glial cells of mouse dorsal root ganglia modulates neuronal excitability in vivo. Pain. 2021. 163 (8), 1636-1647.

Xu Q, Ford NC, He S, Huang Q, Anderson M, Chen Z, Yang F, Crawford LK, Caterina MJ, Guan Y, Dong X. Astrocytes contribute to pain gating in the spinal cord. Sci Adv. 2021; 7: eabi6287.

Meixiong J, Dong X, Weng HJ. Neuropathic Itch. Cells 2020 9 (10), 2263 (Review)

Lay M, Dong X. Neural mechanisms of itch. Annual Review of Neuroscience 2020 43, 187-205 (Review)

Meixiong J, Basso L, Dong X, Gaudenzio N. Nociceptor-Mast Cell Sensory Clusters as Regulators of Skin Homeostasis. Trends in Neurosciences 2020 43 (3), 130-132 (Review)

Patil MJ, Ru F, Sun H, Wang J, Kolbeck RR, Dong X, Kollarik M, Canning BJ, Undem BJ. Acute activation of bronchopulmonary vagal nociceptors by type I interferons. The Journal of Physiology 2020: 98(23): 5541-5554.

Tiwari V, He S-Q, Huang Q, Liang L, Yang F, Chen Z, Tiwari V, Fujita W, Devi LA, Dong X, Guan Y, Raja SN. Activation of µ-δ opioid receptor heteromers inhibits neuropathic pain behavior in rodents. Pain 2020: 161(4): 842-855.

Liu X, Wang H, Jiang Y, Zheng Q, Petrus M, Zhang M, Zheng S, Schmedt C, Dong X, Xiao B. STIM1 Thermosensitivity Defines the Optimal Preference Temperature for Warm Sensation in Mice. Biophysical Journal 2020: 118: 457a.

Limjunyawong N, Dong X. Spicy Immunity: Pain to Gain. Immunity 2019 51 (3), 426-428 (Review)

Green D, Dong X. A Pungent and Painful Toxin. Cell 2019 178 (6), 1279-1281 (Review)

Shiratori-Hayashi M, Hasegawa A, Toyonaga H, Andoh T, Nakahara T, Kido-Nakahara, M., Furue M, Kuraishi Y, Inoue K, Dong X, Tsuda M. Role of P2X3 receptors in scratching behavior in mouse models. Journal of Allergy and Clinical Immunology 2019: 143 (3), 1252-1254.

Wang C, Gu L, Ruan Y, Geng X, Xu M, Yang N, Yu L, Jiang Y, Zhu C, Yang Y, Zhou Y, Guan X, Luo W, Liu Q, Dong X, Yu G, Lan L, Tang Z. Facilitation of MrgprD by TRP-A1 promotes neuropathic pain. The FASEB Journal 2019 33:1360-1373.

Patil MJ, Meeker S, Bautista D, Dong X, Undem BJ. Sphingosine‐1‐phosphate activates mouse vagal airway afferent C‐fibres via S1PR3 receptors. The Journal of physiology 2019 597 (7), 2007-2019

Green DP, Limjunyawong N, Gour N, Pundir P, Dong X. A mast cell specific receptor mediates neurogenic inflammation and pain. Neuron 2019 101: 412-420.

Meixiong J, Anderson M, Limjunyawong N, Sabbagh MF, Hu E, Mack MR, Oetjen LK, Wang F, Kim BS, Dong X. Activation of mast cell-expressed mas-related G-protein-coupled receptors drives non-histaminergic itch. Immunity 2019 50: 1163-1171.

Pundir P, Liu R, Vasavda C, Serhan N, Limjunyawong N, Yee R, Zhan Y, Dong XT, Wu X, Zhang Y, Snyder S, Gaudenzio N, Vidal J, Dong XZ, Identification of mammalian receptors for quorum sensing molecules and their role in antibacterial immunity. Cell Host & Microbe 2019 26:114-122

Meixiong J, Vasavda C, Green D, Zheng Q, Qi L, Kwatra SG, Hamilton JP, Snyder SH, Dong X. Identification of a bilirubin receptor that may mediate a component of cholestatic itch. eLife 2019: 8: e44116.

Meixiong J, Vasavda C, Snyder SH, Dong X. MrgprX4 is a G-protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus. PNAS 2019: 116: 10525-10530.

Limjunyawong N, Dong X. Spicy Immunity: Pain to Gain. Immunity 2019: 51(3): 426-428.

Green D, Dong X. A Pungent and Painful Toxin. Cell 2019: 178(6): 1279-1281.

Tseng PY, Zheng Q, Li Z, Dong X. MrgprX1 mediates neuronal excitability and itch through tetrodotoxin-resistant sodium channels. Itch 2019: 4(3): e28.

Serhan N, Basso L, Sibilano R, Petitfils C, Meixiong J, Bonnart C, Reber LL, Marichal T, Starkl P, Cenac N, Dong X, Tsai M, Galli SJ, Gaudenzio N. House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation. Nature Immunology 2019: 1-9.

Zhang T, Liu R, Che D, Pundir P, Wang N, Han S, Cao J, Lv Y, Dong H, Fang F, Wang J, Ma P, Zhao T, Lei T, Dong X, He L. A Mast Cell–Specific Receptor Is Critical for Granuloma Induced by Intrathecal Morphine Infusion. The Journal of Immunology 2019: 203(7): 1701-1714.

Castro J, Harrington AM, Lieu TM, Garcia-Caraballo S, Maddern J, Schober G, O'Donnell T, Grundy L, Lumsden AL, Miller PE, Ghetti A, Steinhoff MS, Poole DP, Dong X, Chang L, Bunnett NW, Brierley SM. Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity. JCI Insight 2019. 4 (20)

Xu Q, Dong X. Calcium imaging approaches in investigation of pain mechanism in the spinal cord. Experimental Neurology 2019.

Dong X, Dong X. Peripheral and Central Mechanisms of Itch. Neuron 2018 98:482-494. (Review)

Han L, Limjunyawong N, Li Z, Hall OJ, Mitzner W, Undem BJ, Canning BJ, Dong X. Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyperresponsiveness. Nature Neuroscience 2018: 21(3): 324-328.

He SQ, Xu Q, Tiwari V, Yang F, Anderson M, Chen Z, Grenald SA, Raja SN, Dong X, Guan Y. Oligomerization of MrgC11 and μ-opioid receptors in sensory neurons enhances morphine analgesia. Science Signaling 2018: 11(530): eaao3134.

Geng X, Shi H, Ye F, Du H, Qian L, Gu L, Wu G, Zhu C, Yang Y, Wang C, Zhou Y, Yu G, Liu Q, Dong X, Yu L, Tang Z. Matrine inhibits itching by lowering the activity of calcium channels. Scientific Reports 2018: 8: 11328.

Miller RE, Kim YS, Tran PB, Ishihara S, Dong X, Miller RJ, Malfait AM. Visualization of peripheral neuron sensitization in a surgical mouse model of osteoarthritis by in vivo calcium imaging. Arthritis & Rheumatology 2018: 70(1): 88-97.

Zhu S, Zhu J, Zhen G, Hu Y, An S, Li Y, Zheng Q, Chen Z, Yang Y, Wan M, Skolasky RL, Cao Y, Gao B, Yang M, Gao M, Kuliwaba J, Ni S, Wang L, Wu C, Findlay D, Eltzschig HK, Ouyang HW, Crane J, Zhou FQ, Guan Y, Dong X, Cao X. Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. The Journal of Clinical Investigation 2018: 128(11): 4885-4899.

Salvatierra J, Diaz-Bustamante M, Meixiong J, Tierney E, Dong X, Bosmans F. A disease mutation reveals a role for NaV1.9 in acute itch. The Journal of Clinical Investigation 2018: 128(11): 5434-5447.

Tiwari V, Anderson M, Yang F, Tiwari V, Zheng Q, He SQ, Zhang T, Shu B, Chen X, Grenald SA, Stephens KE, Chen Z, Dong X, Raja SN, Guan Y. Peripherally Acting μ-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats. Anesthesiology 2018 128:1220-1236.

Meixiong J, Dong X. Mas-related G protein-coupled receptors and the biology of itch sensation. Annual Review of Genetics 2017 51:103-121. (Review)

Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Leaky gate model: intensity-dependent coding of pain and itch in the spinal cord. Neuron. 2017; 93: 840-853.

Li Z, Tseng PY, Tiwari V, Xu Q, Wang Y, Han L, Wu Z, Cui Y, He SQ, Tiwari V, Sun S, Zheng Q, Cheng Y, Huang J, Geng Y, Xiao B, Peng J, Hopkins CR, Raja SN, Guan Y, Dong X. Targeting human Mas-related G-protein-coupled receptor X1 to inhibit persistent pain. PNAS 2017; 114(10), E1996-E2005.

Anderson M, Zheng Q, Dong X. Investigation of pain mechanisms by calcium imaging approaches. Neuroscience Bulletin 2017: 33(1): 1-6.

Kulkarni S, Micci MA, Leser J, Shin C, Tang SC, Fu YY, Liu L, Li Q, Saha M, Li C, Enikolopov G, Becker L, Rakhilin N, Anderson M, Shen X, Dong X, Butte MJ, Song H, Southard-Smith EM, Kapur RP. Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis. PNAS 2017: 114(14): 3716-3721.

Weng YL, An R, Cassin J, Joseph J, Mi R, Wang C, Zhong C, Jin SG, Pfeifer GP, Bellacosa A, Dong X, Hoke A, He Z, Song H, Ming G. An intrinsic epigenetic barrier for functional axon regeneration. Neuron 2017: 94(2): 337-346.e6.

Ru F, Sun H, Jurcakova D, Herbstsomer RA, Meixiong J, Dong X, Undem BJ. Mechanisms of pruritogen-induced activation of itch nerves in isolated mouse skin. The Journal of Physiology 2017: 595(11): 3651-3666.

Wang J, Kollarik B, Ru F, Sun H, McNeil B, Dong X, Stephens G, Korolevich S, Brohawn P, Kolbeck R, Undem BJ. Distinct and common expression of receptors for inflammatory mediators in vagal nodose versus jugular capsaicin-sensitive/TRPV1-positive neurons detected by low input RNA sequencing. PLOS ONE 2017: 12(10): e0185985.

Salazar TE, Richardson MR, Beli E, Ripsch MS, George J, Kim Y, Duan Y, Moldovan L, Yan Y, Bhatwadekar V, Jadhav V, Smith JA, McGorray S, Bertone AL, Traktuev DO, March KL, Colon-Perez LM, Avin KG, Sims E, Mund JA, Case J, Deng X, Kim MS, McDavitt B, Boulton ME, Thinschmidt J, Calzi SL, Fitz SD, Fuchs RK, Warden SJ, McKinley T, Shekhar A, Febo M, Johnson PL, Chang LJ, Gao Z, Kolonin MG, Lai S, Ma J, Dong X, White FA, Xie H, Yoder MC, Grant MB. Electroacupuncture promotes central nervous system-dependent release of mesenchymal stem cells. Stem Cells 2017: 35(5): 1303-1315.

Meixiong J, Dong X. Mas-related G-protein-coupled receptors and the biology of itch sensation. Annual Review of Genetics 2017: 51(1): 39-62.

Zhang T, Che D, Liu R, Han S, Wang N, Zhan Y, Pundir P, Cao J, Lv Y, Yang L, Wang J, Ding M, Dong X, He L. Typical antimicrobials induce mast cell degranulation and anaphylactoid reactions via MRGPRX2 and its murine homologue MRGPRB2. European Journal of Immunology 2017: 47(11): 1954-1966.

Wang N, Che D, Zhang T, Liu R, Cao J, Wang J, Zhao T, Ma P, Dong X, He L. Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo. Biochemical Pharmacology 2017: 144: 174-182.

Liu R, Che D, Zhao T, Pundir P, Cao J, Lv Y, Wang J, Ma P, Fu J, Wang X, Zhang T, Dong X, He L. MRGPRX2 is essential for sinomenine hydrochloride-induced anaphylactoid reactions. Biochemical Pharmacology 2017: 146: 214-223.

Han S, Lv Y, Kong L, Che D, Liu R, Fu J, Cao J, Wang J, Wang C, He H, Zhang T, Dong X, He L. Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effects of drugs. Scientific Reports 2017: 7: 13714.

Green D, Dong X. The cell biology of acute itch. The Journal of Cell Biology 2016 213 (2), 155-161 (Review)

Sun S, Dong X. Trp channels and itch. Seminars in Immunopathology 2016 38:293-307 (Review)

Tang M, Wu G, Dong X, Tang Z. Phosphoinositide interacting regulator of TRP (Pirt) enhances TRPM8 channel activity in vitro via increasing channel conductance. Acta Pharmacologica Sinica. 2016; 37(1): 98-104.

Wang C, Wang Y, Yang Y, Zhu C, Wu G, Yu G, Jian T, Yang N, Shi H, Tang M, He Q, Lan L, Liu Q, Guan Y, Dong X, Tang JZ. Pirt contributes to uterine contraction-induced pain in mice. Molecular Pain. 2016; 11(1): 1.

Tang M, Wu G, Wang Z, Yang N, Shi H, He Q, Zhu C, Yang Y, Yu G, Wang C, Yuan X, Liu Q, Guan Y, Dong X, Tang Z. Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons. Brain Research. 2016; 1636: 161-171.

Tiwari V, Tiwari V, He S, Zhang T, Raja SN, Dong X, Guan Y. Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy. Translational Research in Pain and Itch. 2016; 87-103.

Tiwari V, Yang F, He S, Shechter R, Zhang C, Shu B, Zhang T, Tiwari V, Wang Y, Dong X, Guan Y, Raja SN. Activation of Peripheral μ-opioid Receptors by Dermorphin d-Arg2, Lys4 Amide Leads to Modality-preferred Inhibition of Neuropathic Pain. Anesthesiology 2016 124 (3), 706-720.

Green D, Dong X. The cell biology of acute itch. The Journal of Cell Biology. 2016; 213(2): 155-161.

Chang AY, Mann TS, McFawn PK, Han L, Dong X, Henry PJ. Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways. Respiratory Research. 2016; 17(1): 1.

Oh Y, Cho GS, Li Z, Hong I, Zhu R, Kim MJ, Kim YJ, Tampakakis E, Tung L, Huganir R, Dong X, Kwon C, Lee G. Functional coupling with cardiac muscle promotes maturation of hPSC-derived sympathetic neurons. Cell Stem Cell. 2016; 19(1): 95-106.

Rakhilin N, Barth B, Choi J, Muñoz NL, Kulkarni S, Jones JS, Small DM, Cheng YT, Cao Y, LaVinka C, Kan E, Dong X, Spencer M, Pasricha P, Nishimura X, Shen X. Simultaneous optical and electrical in vivo analysis of the enteric nervous system. Nature Communications. 2016; 7.

Yang F, Xu Q, Shu B, Tiwari V, He SQ, Vera-Portocarrero LP, Dong X, Linderoth B, Raja SN, Wang Y, Guan Y. Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation. Pain. 2016; 157: 2582-2593.

Kim YS, Anderson M, Park KS, Zheng Q, Agarwal A, Gong C, Saijilafu, Young L, He SQ, LaVinka PC, Zhou F, Bergles D, Hanani M, Guan Y, Spray DC, Dong X. Coupled activation of primary sensory neurons contributes to chronic pain. Neuron. 2016; 91(5): 1085-1096.

Emery EC, Luiz AP, Sikandar S, Magnúsdóttir R, Dong X, Wood JN. In vivo characterization of distinct modality-specific subsets of somatosensory neurons using GCaMP. Science Advances. 2016; 2(11): e1600990.

Wang J, Xu W, Zhong T, Song Z, Zou Y, Ding Z, Guo Q, Dong X, Zou W. miR-365 targets β-arrestin 2 to reverse morphine tolerance in rats. Scientific Reports. 2016; 6: 38285.

Gaudenzio N, Sibilano R, Marichal T, Starkl P, Reber LL, Cenac BD, McNeil C, Dong X, Hernandez JD, Sagi-Eisenberg R, Hammel I, Roers A, Valitutti S, Tsai M, Espinosa E, Galli SJ. Different activation signals induce distinct mast cell degranulation strategies. The Journal of Clinical Investigation. 2016; 126: 3981-3998.

McNeil B, Pundir P, Meeker S, Han L, Undem B, Kulka M, Dong X. Identification of a mast cell specific receptor crucial for pseudo-allergic drug reactions. Nature 2015 519: 237-241.

Weng HJ, Patel K, Jeske NA, Bierbower SM, Zou W, Tiwari V, Zheng Q, Tang Z, Mo G, Wang Y, Geng Y, Zhang J, Guan Y, Akopian A, Dong X. Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain. Neuron 2015 85:833-846.

Gao X, Feng J, Wang W, Xiang Z, Liu X, Zhu C, Tang Z, Dong X, He C. Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3. Nature Communications 6, 2015.

Li Z, He SQ, Tseng PY, Xu Q, Tiwari V, Yang F, Shu B, Zhang T, Tang Z, Raja SN, Wang Y, Dong X, Guan Y. The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms. Neuroscience. 2015 300:393-403.

Reddy VB, Sun S, Azimi E, Elmariah SB, Dong X, Lerner EA. Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs. Nat Communications 2015 6:7864

Green D and Dong X, Supporting itch: a new role for astrocytes in chronic itch. Nature Medicine 2015 21:841-842

Sun S and Dong X. Trp channels and Itch. Seminars in Immunopathology 2015, 1-15.

Han L, Dong X. Itch Mechanisms and Circuits. Annual Review of Biophysics 2014 43: 331-356. (Review)

LaMotte RH, Dong X, Ringkamp M. Sensory Neurons Mediating Itch. Nature Reviews Neuroscience 2014 15:19-31 (Review)

Qu L, Fan N, Shimada S, Ma C, Wang T, Fu K, Han L, Dong X, LaMotte RH. Enhanced excitability of MrgprA3+ and MrgprD+ nociceptors in a model of inflammatory itch and pain. Brain 2014 137: 1039-1050.

He SQ, Li Z, Chu YX, Han L, Xu Q, Yang F, Liu Q, Tang Z, Wang Y, Hin N, Tsukamoto T, Slusher B, Wei F, Raja SN, Dong X, Guan Y. MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain. Pain 2014 155: 534-544.

Kim Y, Chu Y, Han L, Li Z, LaVinka PC, Caterina M, Dubner R, Wei F, and Dong X. Central terminal sensitization of TRPV1 by descending 5-HT facilitation modulates chronic pain. Neuron 2014 81: 873-887.

Li Z, He SQ, Xu Q, Yang F, Tiwari V, Liu, Q, Tang Z, Han L, Chu YX, Wang, Hin N, Tsukamoto T, Slusher B, Guan X, Wei F, Raja SN, Dong X, Guan Y. Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice. Pain 2014 155:1613-1621.

Wooten M, Weng HJ, Hartke T, Borzan J, Klein A, Turnquist B, Dong X, Meyer R, Ringkamp M. Three functionally distinct classes of C-fiber nociceptors in primate. Nature Communications 2014 5: 4122.

Boitano S, Hoffman J, Tillu DV, Asiedu MN, Zhang Z, Sherwood CL, Wang Y, Dong X, Price TJ, Vagner J. Development and evaluation of small peptidominetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering. PLOS One 2014 9: e99140.

Kim YJ, Lim HT, Li Z, Oh Y, Kovlyagina I, Choi IY, Dong X, Lee G. Generation of multipotent induced neural crest by direct reprogramming of human postnatal fibroblasts with a single transcription factor. Cell Stem Cell 2014 15:497-506.

Yang F, Xu Q, Cheong YK, Shechter R, Sdrulla A, He S-Q, Tiwari V, Dong X, Wacnik PW, Meyer RA, Raja SN, Guan Y. Comparison of intensity-dependent inhibition of spinal wide-dynamic range neurons by dorsal column and peripheral nerve stimulation in a rat model of neuropathic pain. European J. Pain 2014 18: 978-88

Hin N, Alt J, Zimmermann SC, Delahanty G, Ferraris DV, Rojas C, Li F, Liu Q, Dong X, Slusher BS, Tsukamoto T. Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of MAS-related gene C (MrgC) receptors. Bioorganic & Medicinal Chemistry 2014 22: 5831-5837. 46 Yang F, Zhang C, Xu Q, Tiwari V, He S-Q, Wang Y, Dong X, Vera-Portocarrero LP, Wacnik PW, Raja SN, Guan Y. Electrical stimulation of dorsal root entry zone attenuates wide-dynamic range neuronal activity in rats. Neuromodulation. 2014 Technology at the Neural Interface 18 (1), 33-40

Yang F, Zhang C, Xu Q, Tiwari V, He S-Q, Wang Y, Dong X, Vera-Portocarrero LP, Wacnik PW, Raja SN, Guan Y. Electrical stimulation of dorsal root entry zone attenuates wide-dynamic range neuronal activity in rats. Neuromodulation. 2014 Technology at the Neural Interface 18 (1), 33-40

Wen W, Wang Y, Li Z, Tseng PY, McManus OB, Wu M, Li M, Lindsley CW, Dong X, Hopkins C. Discovery and characterization of 2-(cyclopropanesulfonamide)-N-(2-ethoxyphenyl) benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 2014 10 (1), 57-61

Doyle J, Kumar K, Dong X, Kopin A. A platform-based approach for peptide drug discovery: generating probes to understand and treat itch. The FASEB Journal. 2014; 28: 2600-2609.

LaVinka PC, Dong X. Molecular signaling and targets from itch: lessons for cough. Cough 2013, 9. (Review)

Han L, Ma C, Liu Q, Weng H, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel K, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte R, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience 2013;16: 174-182.

LaVinka PC, Dong X. Molecular signaling and targets from itch: lessons for cough. Cough 2013, 9.

Zhao X, Tang Z, Zhang H, Atianjoh, FE, Zhao JY, Liang L, Wang W, Guan X, Kao SC, Tiwari V, Gao YJ, Hoffman PN, Cui H, Li M, Dong X, Tao YX. A long noncoding RNA contributes to neuropathic pain by silencing Kv1.2 in primary afferent neurons. Nature Neurosci. 2013: 16: 10-24-1031.

Rose KE, Lunardi N, Boscolo A, Dong X, Jevtovic-Todorovic AE, Todorovic SM. Immunohistological demonstration of Ca_(V3.2) T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse. Neurosci. 2013: 250: 263-274.

He SQ, Yang F, Perez FM, Xu Q, Shechter R, Cheong YK, Carteret AF, Dong X, Sweitzer SM, Raja SN, Guan Y. Tolerance develops to the anti-allodynic effects of the peripherally acting opioid, loperamide hydrochloride, develops in nerve-injured rats. Pain 2013 154: 2477-2486.

Shechter R, Yang F, Xu Q, Cheong YK, He SQ, Sdrulla A, Carteret AF, Wacnik PW, Dong X, Meyer RA, Raja SN, Guan Y. Conventional and kilohertz-frequency spinal cord stimulation produces intensity-and frequency-dependent inhibition of mechanical hypersensitivity in a rat model of neuropathic pain. Anesthesiology 2013 119: 422-432

Tang Z, Kim A, Masuch T, Park K, Weng H, Wetzel C, Dong X. Pirt functions as an endogenous regulator of TRPM8. Nature Communications 4, 2013.

He SQ, Han L, Li Z, Tiwari Vinod, Xu Q, Yang F, Raja SN, Dong X, Guan Y. Nerve injury induced different changes of MrgC expression in injured versus uninjured afferent sensory neurons. Neuroscience 2013 261: 43-51.

McNeil B, Dong X. Peripheral mechanisms of itch. Neuroscience Bulletin 2012 28: 100-110. (Review)

Chung, CY, Carteret AF, McKelvy AD, Ringkamp M, Yang F, Hartke TV, Dong X, Raja SN, Guan Y. Analgesic properties of loperamide differ following systemic and local administration to rats after L5 spinal nerve injury. Eur J Pain. 2012 16: 1021-1032.

McNeil B, Dong X. Peripheral mechanisms of itch. Neuroscience Bulletin 2012: 28: 100-110.

Liu T, Berta T, Xu ZZ, Park CK, Zhang L, Lü N, Liu Q, Liu Y, Gao YJ, Liu YC, Ma Q, Dong X, Ji RR. TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. J Clin Invest. 2012 122: 2195-2207.

Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF. Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci. 2012 15: 836-844.

Chung MK, Jue SS, Dong X. Projection of Non-peptidergic afferents to mouse tooth pulp. J Dent Res. 2012 91(8):777-82

Liu Q, Sikand P, Ma C, Tang Z, Han L, Zhe Li, Sun S., LaMotte R, Dong X. The mechanisms of itch evoked by -alanine. J Neurosci. 2012 32(42):14532-14537.

Patel KN, Dong X. Itch: molecules, cells, and circuits. ACS Chemical Neuroscience 2011: 2: 17-25 (Review)

Patel KN, Dong X. Itch: molecules, cells, and circuits. ACS Chemical Neuroscience 2011: 2: 17-25

Wilson SR, Gerhold K, Bifolck-Fisher A, Liu Q, Patel KN, Dong X, Bautista DM. TRPA1 is required for histamine-independent, Mas-related G protein coupled receptor-mediated itch. Nature Neurosci. 2011:14: 595-603

Sikand P, Dong X, LaMotte RH. BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release. J Neuroscience 2011: 21: 7563-7;

Patel K, Liu Q, Meeker S, Undem BJ, Dong X. Pirt, a TRPV1 modulator, is required for histamine- dependent and independent itch. PLoS ONE 2011: 6: e20559

Liu Q, Weng H, Patel KN, Tang Z, Bai H, Dong X. The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. Science Signaling 2011: 4

Yang F, Carteret AF, Wacnik WP, Chung CY, Xing L, Dong X, Meyer RA, Raja SN, Guan Y. Bipolar spinal cord stimulation attenuates mechanical hypersensitivity at an intensity that activates a small portion of A-fiber afferents in spinal nerve-injured rats. Neuroscience 2011: 199:470-480.

Patel KN, Dong X. An itch to be scratched. Neuron 2010: 68:334-339 (Review)

Guan Y, Liu Q, Tang Z, Raja SN, Anderson DJ, Dong X. Mas-related G-protein-coupled receptors inhibit pathological pain in mice. PNAS 2010: 107: 15933-8.

Patel KN, Dong X. An itch to be scratched. Neuron 2010: 68:334-339

Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, Ru F, Guan Y, Weng H, Geng Y, Undem BJ, Kollarik M, Chen ZF, Anderson DJ, Dong X. Sensory neuron-specific GPCRs Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell 2009: 139: 1353-1365.

Pereira E, Grant JA, Huang YA, Dong X, Roper SD. Glutamatergic and catecholaminergic markers are present in fibers innervating mouse taste buds. Chemical Senses.

Liu Y, Yang FC, Okuda T, Dong X, Zylka MJ, Chen CL, Anderson DJ, Kuner R, Ma Q. Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors. J Neuroscience 2008: 28:125-32.

Lee M, Dong X, Liu Q, Patel KN, Choi OH, Vonakis B, Undem BJ. Agonists of the Mas Related Gene (Mrgs) Orphan Receptors as Novel Mediators of Mast Cell-Sensory Nerve Interactions. J Immunology 2008: 180: 2251-2255. Corresponding author and co-first author

Kim AY, Tang Z, Liu Q, Patel KN, Maag D, Geng Y, Dong X. Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell 2008: 133: 475-485.

Fiacco TA, Agulhon C, Taves SR, Petravicz J, Casper KB, Dong X, Chen J, McCarthy KD. Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activity. Neuron 2007: 54: 611-26.

Liu Q, Vrontou S, Rice F, Zylka MJ, Dong X, Anderson DJ. Genetic visualization of candidate C-fiber sensory neurons that detect pleasant touch. Nature Neuroscience 2007: 10: 946-8 Co-corresponding author

Zylka MJ, Dong X, Southwell AL, Anderson DJ. Atypical expansion in mice of the sensory neuron specific Mrg G protein-coupled receptor family. PNAS 2003: 100: 10043-10048.

Han S, Dong X, Hwang J, Zylka MJ, Anderson DJ, Simon MI. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the G_(q/11) pathway. PNAS 2002: 99: 14740-14745.

Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 2001: 106: 619-632.

Dong X, Tsuda L, Zavitz KH, Zipursky SL. Ebi is a WD-repeat-containing protein required for EGF receptor signaling in Drosophila. Genes & Development 1999: 13: 954-965.

Jackson GR, Salecker I, Dong X, Yao X, Arneim N, Faber PW, MacDonald ME, Zipursky SL. Polyglutamine-expanded human Huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron 1998: 21: 633-642.

Dong X, Zavitz KH, Thomas BJ, Lin M, Campbell S, Zipursky SL. Control of G1 in the developing Drosophila eye: rca1 regulates cyclin A. Genes & Development 1997: 11: 94-105.

Thomas BJ, Zavitz KH, Dong X, Lane ME, Weigmann K, Lehner C, Finley R, Brent R, Zipursky. Roughex downregulates G2 cyclins in G1. Genes & Development 1997: 11: 1289-1298.